Summary: Paracetamol remains one of the most commonly used analgesic and antipyretic drugs worldwide, and its clinical importance stems from its favorable safety profile, efficacy, and suitability for use in patients with contraindications to nonsteroidal anti-inflammatory drugs (NSAIDs). Recent studies indicate that its mechanism of action is multifaceted and involves not only inhibition of prostaglandin synthesis within the central nervous system, but also modulation of descending serotonergic pathways and interaction with the endocannabinoid system via the metabolite AM404. Paracetamol is used both as monotherapy and for co-analgesia, including in combination with opioids. In pain management, particularly in acute pain, the importance of a rapid onset of action is emphasized. This parameter affects not only the clinical efficacy but also patient satisfaction and improves treatment compliance. This article discusses the importance of pharmaceutical formulations of paracetamol characterized by a rapid onset of action, with particular emphasis on effervescent formulations. Due to the prior dissolution of the active substance and the presence of sodium bicarbonate, this formulation promotes faster gastric emptying, a shorter time to reach maximum plasma concentration (Tmax), and higher plasma drug concentrations during the early phase after administration compared with conventional tablets. This translates into a faster onset of analgesic and antipyretic effects, making this formulation particularly useful in postoperative pain, dental pain, headaches, and effective antipyretic therapy.